Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BBOX1 | O75936 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL15577133 | 1.00 | BBOX1 (0.43) | BBOX1MEN1LMNAKMT2ACYP3A4 | |
| D-Glutamate SCHEMBL8218834 | 0.88 | CYP1A2 (0.46) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| D-Glutamate SCHEMBL29267391 | 0.85 | BBOX1 (0.52) | BBOX1KMT2ACA1CPT2CPT1A | |
| D-Glutamate SCHEMBL32681788 | 0.83 | BBOX1 (0.50) | BBOX1KMT2ACA1CPT2CPT1A | |
| Aspartic Acid SCHEMBL31756854 | 0.82 | CPT2 (0.48) | BBOX1MEN1LMNAKMT2ACYP3A4 | |
| Aspartic Acid SCHEMBL6033507 | 0.82 | CPT2 (0.48) | BBOX1MEN1LMNAKMT2ACYP3A4 | |
| Choline SCHEMBL1683103 | 0.82 | LMNA (0.46) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Ornithine SCHEMBL21046000 | 0.81 | GSR (0.39) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| D-Glutamate SCHEMBL28892969 | 0.81 | CA1 (0.46) | BBOX1KMT2ACYP3A4CA1CA2 | |
| D-Glutamate SCHEMBL27976324 | 0.81 | CA1 (0.46) | BBOX1KMT2ACYP3A4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059446-A1 | MULTIVALENT IONIC LIQUIDS AS PROCESS AIDS FOR BITUMEN EXTRACTION | STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) | 2025-02-20 | — | — | US | claimed |
| CN-117343967-A | Direct current is utilized in separationCoupling multienzyme system strengthening CO in sub-liquid 2 Reduction method and application | 河南工业大学 | 2024-01-05 | — | — | CN | claimed |
| CN-116656753-A | Efficient and continuous phospholipid type arachidonic acid enzymatic method | 江南大学 | 2023-08-29 | — | — | CN | claimed |
| CN-114044852-B | Polymerizable eutectic solvent, conductive elastomer and preparation method of conductive elastomer | 江南大学 | 2022-11-22 | — | — | CN | claimed |
| CN-114044852-A | Polymerizable eutectic solvent, conductive elastomer and preparation method thereof | 江南大学 | 2022-02-15 | — | — | CN | claimed |
| CN-109627122-A | A kind of biogas residue farmland compound fertilizer and preparation method thereof | 山东省农业科学院作物研究所 | 2019-04-16 | — | — | CN | claimed |
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | claimed |
| US-20250059446-A1 | MULTIVALENT IONIC LIQUIDS AS PROCESS AIDS FOR BITUMEN EXTRACTION | STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) | 2025-02-20 | — | — | US | disclosed |
| CN-114621984-B | Method for synthesizing 1, 5-pentanediamine by using ionic liquid to strengthen lysine decarboxylase | 中国科学院过程工程研究所 | 2025-01-28 | — | — | CN | disclosed |
| US-20240226045-A9 | RUMEN-PROTECTED COMPOSITIONS AND METHODS OF MAKING THE SAME | BALCHEM CORPORATION | 2024-07-11 | — | — | US | disclosed |
| WO-2024092005-A2 | RUMEN-PROTECTED COMPOSITIONS AND METHODS OF MAKING THE SAME | BALCHEM CORPORATION (US) | 2024-05-02 | — | — | WO | disclosed |
| US-20240130991-A1 | RUMEN-PROTECTED COMPOSITIONS AND METHODS OF MAKING THE SAME | BALCHEM CORP (US) | 2024-04-25 | — | — | US | disclosed |
| CN-116656753-A | Efficient and continuous phospholipid type arachidonic acid enzymatic method | 江南大学 | 2023-08-29 | — | — | CN | disclosed |
| WO-2018119152-A1 | SYNTHESIS OF BIOPRODUCTS FROM LIGNIN-DERIVED AROMATICS BY GENETICALLY MODIFIED MICROORGANISMS | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (NTESS) (US) | 2018-06-28 | — | — | WO | disclosed |
| US-20170247729-A1 | SWITCHABLE IONIC LIQUIDS FOR BIOMASS PRETREATMENT AND ENZYMATIC HYDROLYSIS | UNITED STATES DEPARTMENT OF ENERGY | 2017-08-31 | — | — | US | disclosed |
| WO-2016070125-A1 | SWITCHABLE IONIC LIQUIDS FOR BIOMASS PRETREATMENT AND ENZYMATIC HYDROLYSIS | SANDIA CORPORATION (US) | 2016-05-06 | — | — | WO | disclosed |
| EP-2895071-A1 | ROD SHAPED IMPLANTABLE BIOSENSOR | Brains Online Holding B.V. (NL) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014041190-A1 | ROD SHAPED IMPLANTABLE BIOSENSOR | BRAINS ONLINE HOLDING B.V. (NL) | 2014-03-20 | — | — | WO | disclosed |
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | disclosed |
| US-5187093-A | Pure culture from which microorganisms which are stable, do not catabolize carnitine and grow with betaine are chosen | LONZA LTD. (CH) | 1993-02-16 | — | — | US | disclosed |