Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.60 |
| ▸ | ASPH | Q12797 | 10/20 | 0.60 |
| ▸ | KDM8 | Q8N371 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RIOX2 | Q8IUF8 | 7/20 | 0.45 |
| ▸ | DDT | P30046 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26140194 | 0.82 | KDM4E (0.46) | KDM4EASPHKDM8ALDH1A1RIOX2 | |
| SCHEMBL2249284 | 0.81 | HSD17B10 (0.43) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL1171098 | 0.80 | KDM4E (0.67) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL27106805 | 0.79 | KDM4E (0.48) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL21826652 | 0.79 | AKR1C4 (0.44) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL3879991 | 0.78 | ALDH1A1 (0.49) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL2262851 | 0.78 | KDM4E (0.47) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL31090134 | 0.78 | KDM4E (0.47) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL1180456 | 0.78 | KDM4E (0.52) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 | |
| SCHEMBL4790109 | 0.78 | GABRP (0.56) | KDM4EASPHKDM8ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492187-B2 | Factor XI activation inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-12-09 | — | — | US | disclosed |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4125892-A1 | FACTOR XI ACTIVATION INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021202254-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-10-07 | — | — | WO | disclosed |
| WO-2021202254-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-10-07 | — | — | WO | disclosed |
| EP-2816038-B1 | HOPO CHELATORS | LUMIPHORE INC (US) | 2019-11-20 | — | — | EP | disclosed |
| US-10352938-B2 | Macrocyclic HOPO chelators | LUMIPHORE, INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-20160320399-A1 | MACROCYCLIC HOPO CHELATORS | LUMIPHORE, INC. | 2016-11-03 | — | — | US | disclosed |
| EP-2470513-B1 | MACROCYCLIC HOPO CHELATORS | LUMIPHORE INC (US) | 2014-10-08 | — | — | EP | disclosed |
| US-20120214253-A1 | MACROCYCLIC HOPO CHELATORS | LUMIPHORE, INC. (US) | 2012-08-23 | — | — | US | disclosed |
| EP-2470513-A1 | MACROCYCLIC HOPO CHELATORS | Lumiphore, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025790-A1 | MACROCYCLIC HOPO CHELATORS | LUMIPHORE, INC. (US) | 2011-03-03 | — | — | WO | disclosed |
| US-5356909-A | Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| EP-0281943-B1 | Substituted pyridine-2,4-carboxylic acid derivatives, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AG (DE) | 1994-01-12 | — | — | EP | disclosed |
| EP-0548883-A1 | Substituted pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-30 | — | — | EP | disclosed |
| US-5143926-A | Substituted pyridine-2,4-dicarboxylic acid compounds and methods of use thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-01 | — | — | US | disclosed |
| US-5004748-A | Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-02 | — | — | US | disclosed |
| EP-0281943-A2 | Substituted pyridine-2,4-carboxylic acid derivatives, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492187-B2 | Factor XI activation inhibitors | F11, TFPI, F13B | KDM4E 1614/4885ASPH 890/4885KDM8 476/4885 |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | F11, TFPI, F13B | KDM4E 1614/4885ASPH 890/4885KDM8 476/4885 |
| US-20160320399-A1 | MACROCYCLIC HOPO CHELATORS | PHPT1, SSB, CD69 | KDM4E 2605/4885ASPH 1698/4885KDM8 1771/4885 |
| US-20120214253-A1 | MACROCYCLIC HOPO CHELATORS | PHPT1, SSB, CD69 | KDM4E 2605/4885ASPH 1698/4885KDM8 1771/4885 |
| US-10352938-B2 | Macrocyclic HOPO chelators | PHPT1, SSB, CD69 | KDM4E 2605/4885ASPH 1698/4885KDM8 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.