Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220477 | 1.00 | KDM4E (0.70) | KDM4EALDH1A1MAPTGSK3BHPGD | |
| SCHEMBL8220485 | 1.00 | KDM4E (0.70) | KDM4EALDH1A1MAPTGSK3BHPGD | |
| SCHEMBL8218393 | 0.91 | KDM4E (0.66) | KDM4EALDH1A1MAPTGSK3BHPGD | |
| SCHEMBL8218397 | 0.91 | KDM4E (0.66) | KDM4EALDH1A1MAPTGSK3BHPGD | |
| SCHEMBL8218399 | 0.91 | KDM4E (0.66) | KDM4EALDH1A1MAPTGSK3BHPGD | |
| SCHEMBL31428766 | 0.83 | ALDH1A1 (0.62) | KDM4EALDH1A1MAPTGSK3BHPGD | |
| SCHEMBL5692309 | 0.81 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL31428602 | 0.81 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL3125849 | 0.76 | GSK3B (0.70) | KDM4EALDH1A1MAPTGSK3BPOLB | |
| SCHEMBL3125853 | 0.76 | GSK3B (0.70) | KDM4EALDH1A1MAPTGSK3BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | claimed |
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | disclosed |