SCHEMBL3125849

SCHEMBL3125849

COc1ccc(/C=C2\NC(=O)NC2=O)cc1OC

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GSK3B P49841 7/20 0.70
▸ MAPK1 P28482 2/20 0.67
▸ CLK1 P49759 1/20 0.65
▸ DYRK1A Q13627 1/20 0.65
▸ POLB P06746 3/20 0.61
▸ NCOA3 Q9Y6Q9 2/20 0.61
▸ NCOA1 Q15788 1/20 0.61
▸ CBS P35520 1/20 0.59
▸ PDE4B Q07343 2/20 0.58
▸ PIM1 P11309 1/20 0.58
▸ PIM3 Q86V86 1/20 0.58
▸ PIM2 Q9P1W9 1/20 0.58
▸ MAPT P10636 4/20 0.57
▸ MEN1 O00255 2/20 0.57
▸ KMT2A Q03164 2/20 0.57
▸ ALDH1A1 P00352 1/20 0.57
▸ KDM4E B2RXH2 1/20 0.55
▸ BLM P54132 1/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.55
▸ PDE3A Q14432 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15421424 1.00 GSK3B (0.70) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL3125853 1.00 GSK3B (0.70) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL9282567 0.88 CBS (0.78) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL9282569 0.88 CBS (0.78) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL15421730 0.87 GSK3B (0.61) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL9252149 0.87 MEN1 (0.77) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL15421733 0.87 GSK3B (0.61) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL15421749 0.87 MEN1 (0.77) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL15421732 0.87 GSK3B (0.61) GSK3BMAPK1CLK1DYRK1APOLB
SCHEMBL9252144 0.87 MEN1 (0.77) GSK3BMAPK1CLK1DYRK1APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160102065-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) 2016-04-14 — — US claimed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 — — US claimed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 — — US claimed
EP-1370232-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2003-12-17 — — EP claimed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 — — US claimed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 — — US claimed
EP-1317918-A1 Cosmetic sunscreen compositions based on synergistic filter mixture and their use L'OREAL (FR) 2003-06-11 — — EP claimed
WO-2002056858-A1 SOLAR PROTECTION COMPOSITIONS L'OREAL (FR) 2002-07-25 — — WO claimed
WO-2002049597-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2002-06-27 — — WO claimed
JP-2111760-A — — None — — JP disclosed
JP-5186429-A — — None — — JP disclosed
EP-3709966-B1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT OREAL (FR) 2024-12-11 — — EP disclosed
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 — — US disclosed
EP-3185843-B1 GEL COMPOSITION AND GEL COMPRISING A UV FILTER OREAL (FR) 2021-08-11 — — EP disclosed
JP-H05186429-A BENZYLIDENEHYDANTOIN DERIVATIVE AND SKIN EXTERNAL PREPARATION BLENDED WITH THE SAME SHISEIDO CO LTD 1993-07-27 — — JP disclosed
US-5087729-A Sunscreen agents AJINOMOTO CO., INC. (JP) 1992-02-11 — — US disclosed
US-5000945-A Method of stabilizing a UVB absorbing compound, a stabilized UV absorber, and a cosmetic composition containing the same AJINOMOTO CO., INC. (JP) 1991-03-19 — — US disclosed
US-4985237-A Benzylidene compounds, cosmetic compositions containing the same and ultraviolet absorber comprising the same AJINOMOTO CO., INC. (JP) 1991-01-15 — — US disclosed
JP-H02111760-A HYDANTOIN DERIVATIVE SHOWA DENKO KK 1990-04-24 — — JP disclosed
US-4797493-A ULTRAVIOLET RADIATION ABSORBERS TO PROTECT SKIN AJINOMOTO CO., INC. (JP) 1989-01-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SUCLG1, CUTA, DLD GSK3B 2485/4885MAPK1 4298/4885CLK1 3779/4885
US-20160102065-A1 NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF PPARG, PPARA, TYR GSK3B 3223/4885MAPK1 1656/4885CLK1 3520/4885
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 GSK3B 4194/4885MAPK1 3934/4885CLK1 937/4885
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS HADHB, SDHA, ERCC4 GSK3B 2290/4885MAPK1 3223/4885CLK1 3658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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