Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219871 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EHSD17B10PARP1PRKCI | |
| SCHEMBL34473210 | 0.80 | KMT2A (0.46) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL8212270 | 0.79 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL7796061 | 0.73 | MAPT (0.63) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL20406100 | 0.71 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL24861080 | 0.71 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL13323912 | 0.71 | MAPT (0.44) | ALDH1A1KDM4EMAPTMEN1RAB9A | |
| SCHEMBL8220603 | 0.71 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10PARP1PRKCI | |
| SCHEMBL12880138 | 0.71 | MAPT (0.75) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL29512056 | 0.71 | MAPT (0.75) | ALDH1A1HPGDKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008019303-A2 | PYRIDAZINONYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |