Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.43 |
| ▸ | PDE9A | O76083 | 2/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13323945 | 0.84 | SMN1; SMN2 (0.39) | MAPTALDH1A1SMN1; SMN2RAB9ANPBWR1 | |
| SCHEMBL13323884 | 0.81 | NPBWR1 (0.48) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13323939 | 0.75 | SMN1; SMN2 (0.38) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13324025 | 0.75 | NPBWR1 (0.43) | MAPTALDH1A1SMN1; SMN2NPBWR1PDE9A | |
| SCHEMBL13324015 | 0.73 | ALOX5 (0.37) | ALDH1A1SMN1; SMN2NPBWR1PDE9AKDM4E | |
| SCHEMBL10072551 | 0.72 | SMN1; SMN2 (0.51) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL13323954 | 0.71 | PPARG (0.39) | ALDH1A1SMN1; SMN2NPBWR1KDM4ECYP1A2 | |
| SCHEMBL8220809 | 0.71 | ALDH1A1 (0.50) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7796061 | 0.70 | MAPT (0.63) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13323993 | 0.68 | NPBWR1 (0.38) | ALDH1A1SMN1; SMN2NPBWR1PDE9APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718612-B2 | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | ENANTA PHARMACEUTICALS, INC. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | PRSS1, SPINT2, TMPRSS4 | MAPT 4248/4885ALDH1A1 975/4885MEN1 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.