Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211527 | 0.81 | KLKB1 (0.45) | KLKB1EPHX1EPHX2RAB9AGAA | |
| SCHEMBL8212640 | 0.81 | PIK3CA (0.51) | KLKB1EPHX1RAB9AGAAKDR | |
| SCHEMBL8222628 | 0.81 | KLKB1 (0.44) | KLKB1EPHX1EPHX2RAB9AGAA | |
| SCHEMBL8222594 | 0.81 | PIK3CA (0.43) | KLKB1EPHX1RAB9AGAAKDR | |
| SCHEMBL11925988 | 0.80 | RAB9A (0.52) | EPHX1EPHX2RAB9AGAAKDR | |
| SCHEMBL3601838 | 0.80 | PIK3CA (0.58) | PIK3CAMTOR | |
| SCHEMBL8211534 | 0.79 | KLKB1 (0.41) | KLKB1EPHX1EPHX2RAB9AGAA | |
| SCHEMBL11926124 | 0.79 | KLKB1 (0.41) | KLKB1EPHX1RAB9AGAAKDR | |
| SCHEMBL8214242 | 0.78 | CYP3A4 (0.44) | EPHX1EPHX2RAB9AGAAPIK3CA | |
| SCHEMBL8219567 | 0.78 | PIK3CA (0.42) | KLKB1EPHX1RAB9AGAAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |