Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19105550 | 0.85 | ALDH1A1 (0.42) | ADRA2BADRA2CSLC6A2HTR2ASLC6A4 | |
| SCHEMBL8422447 | 0.80 | CYP2C19 (0.53) | ADRA2BADRA2CSLC6A2HTR2ASLC6A4 | |
| SCHEMBL15071812 | 0.80 | GBA1 (0.46) | ADRA2BADRA2CSLC6A2HTR2ASLC6A4 | |
| SCHEMBL16310946 | 0.73 | CAPN1 (0.44) | HTR2ALMNAAOC3TAAR1 | |
| SCHEMBL29957104 | 0.72 | CXCR1 (0.52) | ADRA2BADRA2CSLC6A2HTR2ASLC6A4 | |
| SCHEMBL12609970 | 0.72 | TSHR (0.64) | ADRA2BADRA2CSLC6A2HTR2ASLC6A4 | |
| SCHEMBL12794282 | 0.71 | HDAC6 (0.47) | MAPK1TSHRCYP2C19MEN1KMT2A | |
| SCHEMBL19117565 | 0.70 | NPC1 (0.61) | ALDH1A1MEN1KMT2A | |
| SCHEMBL12774503 | 0.69 | CRHBP (0.54) | ADRA2BADRA2CSLC6A2HTR2ASLC6A4 | |
| SCHEMBL13561359 | 0.68 | HTR2B (0.44) | LMNAALDH1A1CNR2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | SCHERING CORPORATION | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | CNR2, GPR119, GLP1R | ADRA2B 106/4885ADRA2C 71/4885SLC6A2 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.