Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 13/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218968 | 0.88 | CACNA1B (0.35) | CACNA1BKDM4EALDH1A1MAPTADORA3 | |
| SCHEMBL8222248 | 0.86 | GAA (0.43) | CACNA1BKDM4EALDH1A1TP53CYP1A2 | |
| SCHEMBL8224837 | 0.84 | CACNA1B (0.32) | CACNA1BKDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL8224820 | 0.79 | CACNA1B (0.35) | CACNA1BKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL8223286 | 0.75 | CACNA1B (0.33) | CACNA1BKDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL8222581 | 0.75 | KDM4E (0.48) | CACNA1BKDM4EALDH1A1MAPTADORA3 | |
| SCHEMBL8222583 | 0.74 | KDM4E (0.52) | CACNA1BKDM4EALDH1A1MAPTADORA3 | |
| SCHEMBL8225874 | 0.73 | CACNA1F (0.51) | KDM4EALDH1A1MAPTADORA3CACNA1F | |
| SCHEMBL8222271 | 0.72 | KDM4E (0.48) | KDM4EALDH1A1MAPTADORA3CACNA1F | |
| SCHEMBL8214725 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1MAPTADORA3CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |