Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224837 | 0.83 | CACNA1B (0.32) | CACNA1BALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL8218968 | 0.79 | CACNA1B (0.35) | CACNA1BALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL8224367 | 0.79 | CACNA1B (0.35) | CACNA1BALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL8222248 | 0.78 | GAA (0.43) | CACNA1BALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL8223286 | 0.76 | CACNA1B (0.33) | CACNA1BALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL8222259 | 0.68 | MAPK1 (0.56) | ALDH1A1KDM4EHSD17B10TSHRHPGD | |
| SCHEMBL8222581 | 0.67 | KDM4E (0.48) | CACNA1BALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL11819754 | 0.66 | KDM4E (0.66) | ALDH1A1KDM4EHSD17B10TSHRHPGD | |
| SCHEMBL8222583 | 0.66 | KDM4E (0.52) | CACNA1BALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL7341175 | 0.66 | CACNA1B (0.64) | CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |