Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 5/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289873 | 0.87 | DPYD (1.00) | DPYDMAPTALDH1A1GAAATAD2 | |
| 5-Bromouracil SCHEMBL29805 | 0.87 | — | — | |
| SCHEMBL7884 | 0.87 | — | — | |
| SCHEMBL7250168 | 0.76 | DPYD (0.76) | DPYDMAPTALDH1A1GAAATAD2 | |
| 5-Bromouracil SCHEMBL2153057 | 0.76 | GAA (0.47) | DPYDMAPTALDH1A1GAAATAD2 | |
| 5-Bromouracil SCHEMBL5449794 | 0.76 | DPYD (0.42) | DPYDMAPTALDH1A1GAAATAD2 | |
| 5-Bromouracil SCHEMBL1079108 | 0.76 | MAPT (0.76) | DPYDMAPTALDH1A1GAAATAD2 | |
| SCHEMBL14793573 | 0.74 | DPYD (0.66) | DPYDMAPTALDH1A1GAAATAD2 | |
| 5-Bromouracil SCHEMBL28326183 | 0.73 | ALDH1A1 (0.42) | DPYDMAPTALDH1A1GAAATAD2 | |
| Hypoxanthine SCHEMBL28275165 | 0.69 | ALDH1A1 (0.60) | DPYDMAPTALDH1A1GAAATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462152-A1 | COMPOSITION AND METHODS OF TREATING VIRAL INFECTIONS AND VIRAL INDUCED TUMORS | Chimerix, Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011017253-A1 | COMPOSITION AND METHODS OF TREATING VIRAL INFECTIONS AND VIRAL INDUCED TUMORS | CHIMERIX, INC. (US) | 2011-02-10 | — | — | WO | disclosed |