Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219137 | 0.86 | KDM4E (0.48) | NPC1RAB9AMEN1KMT2APTGS2 | |
| SCHEMBL13594777 | 0.85 | CYP11B1 (0.49) | CYP11B1CYP11B2NPC1RAB9AMEN1 | |
| SCHEMBL13595004 | 0.85 | CYP11B1 (0.49) | CYP11B1CYP11B2NPC1RAB9AMEN1 | |
| SCHEMBL12669909 | 0.85 | CYP11B1 (0.49) | CYP11B1CYP11B2NPC1RAB9AMEN1 | |
| SCHEMBL8226827 | 0.79 | TRPA1 (0.56) | NPC1RAB9AALOX5PTGS2CYP1A1 | |
| SCHEMBL7936491 | 0.76 | MEN1 (0.41) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL15958645 | 0.75 | MAPT (0.52) | NPC1RAB9AMEN1KMT2APTGS1 | |
| SCHEMBL8212824 | 0.75 | ALOX5 (0.38) | NPC1RAB9AMEN1KMT2AALOX5 | |
| SCHEMBL9000529 | 0.75 | CYP11B1 (0.69) | CYP11B1CYP11B2NPC1RAB9AMEN1 | |
| SCHEMBL9000534 | 0.75 | CYP11B1 (0.69) | CYP11B1CYP11B2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809264-B2 | Quinoxalinyl macrocyclic hepatitis C virus serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-7635683-B2 | Quinoxalinyl tripeptide hepatitis C virus inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |
| WO-2008002924-A2 | QUINOXALINYL MACROCYCLIC HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-01-03 | — | — | WO | disclosed |