Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | S100A4 | P26447 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | HBB | P68871 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10435447 | 0.86 | RELA (0.63) | MAPTMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL10371974 | 0.86 | RELA (0.63) | MAPTMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL12676802 | 0.85 | S100A4 (0.50) | MAPTMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL12669913 | 0.85 | MAPT (0.49) | MAPTMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL8219137 | 0.85 | KDM4E (0.48) | MAPTMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL8226827 | 0.84 | TRPA1 (0.56) | MAPTRAB9AKDM4EL3MBTL1RELA | |
| SCHEMBL14619409 | 0.79 | MAPT (0.55) | MAPTMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL10435351 | 0.77 | APP (0.61) | MAPTMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL8224935 | 0.75 | CYP11B1 (0.53) | MEN1KMT2ARAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL30464972 | 0.75 | MAPT (0.61) | MAPTMEN1KMT2ARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809264-B2 | Quinoxalinyl macrocyclic hepatitis C virus serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |