Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.41 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15066404 | 0.98 | HTT (0.44) | PNMTHTTP2RX7CD38ALDH1A1 | |
| SCHEMBL28046920 | 0.80 | P2RX7 (0.48) | P2RX7CD38ALDH1A1MAPTCFD | |
| SCHEMBL13886573 | 0.80 | SLC6A2 (0.47) | HTTP2RX7CD38ALDH1A1TAAR1 | |
| SCHEMBL16385710 | 0.80 | HTT (0.41) | PNMTHTTP2RX7CD38ALDH1A1 | |
| SCHEMBL6068499 | 0.79 | MAPT (0.41) | HTTP2RX7ALDH1A1GAAMAPT | |
| SCHEMBL8224664 | 0.79 | PNMT (0.61) | PNMTP2RX7ALDH1A1GAAMAPT | |
| SCHEMBL6068451 | 0.79 | PNMT (0.56) | PNMTHTTALDH1A1GAAMAPT | |
| SCHEMBL559225 | 0.79 | PNMT (0.67) | PNMTMPOTAAR1CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL6252762 | 0.78 | SLC6A2 (0.46) | HTTP2RX7CD38ALDH1A1TAAR1 | |
| SCHEMBL23368473 | 0.78 | MEN1 (0.48) | HTTP2RX7CD38ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713985-B2 | Adenosine Aa2 receptor antagonists | SCHERING CORPORATION (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713985-B2 | Adenosine Aa2 receptor antagonists | SCHERING CORPORATION (US) | 2010-05-11 | — | — | US | disclosed |
| EP-2038285-B1 | ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2010-02-17 | — | — | EP | disclosed |
| US-20080255156-A1 | ADENOSINE A2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2008-10-16 | — | — | US | disclosed |
| US-20080255156-A1 | ADENOSINE A2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2008-10-16 | — | — | US | disclosed |
| WO-2008002596-A2 | ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255156-A1 | ADENOSINE A2A RECEPTOR ANTAGONISTS | ADORA3, ADORA2A, ADORA1 | PNMT 1978/4885HTT 876/4885P2RX7 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.