Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.54 |
| ▸ | GCGR | P47871 | 1/20 | 0.52 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846077 | 0.87 | HMGCR (0.54) | HMGCRGCGRSQORTOP1ADORA2A | |
| SCHEMBL8878341 | 0.87 | HMGCR (0.57) | HMGCRSQORTOP1ADORA2AADORA1 | |
| SCHEMBL8953106 | 0.85 | HMGCR (0.58) | HMGCR | |
| SCHEMBL8953098 | 0.85 | HMGCR (0.58) | HMGCR | |
| SCHEMBL22604014 | 0.85 | HMGCR (0.56) | HMGCRSQOR | |
| SCHEMBL8878203 | 0.85 | HMGCR (0.57) | HMGCRSQORTOP1ADORA2AADORA1 | |
| SCHEMBL8878191 | 0.85 | HMGCR (0.57) | HMGCRSQORTOP1ADORA2AADORA1 | |
| SCHEMBL8876495 | 0.84 | HMGCR (0.54) | HMGCRGCGRSQORTOP1ADORA2A | |
| SCHEMBL10024048 | 0.81 | SQOR (0.48) | HMGCRGCGRSQORTOP1ADORA2A | |
| SCHEMBL10345761 | 0.77 | HPGD (0.49) | HMGCRGCGRSQORTOP1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363130-A1 | Combination of HMG-CoA reductase inhibitors with phosphodiesterase 4 inhibitors for the treatment of inflammatory pulmonary diseases | Nycomed GmbH (DE) | 2011-09-07 | — | — | EP | disclosed |
| WO-2008003701-A2 | COMBINATION OF HMG-COA REDUCTASE INHIBITORS WITH PHOSPHODIESTERASE 4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES | NYCOMED GMBH (DE) | 2008-01-10 | — | — | WO | disclosed |
| US-4898868-A | ANTICHOLESTEROL AGENTS; LACTONE OR FREE ACID FORM | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |