Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596005 | 0.92 | LMNA (0.44) | PKMALDH1A1CYP1A2LMNATSHR | |
| SCHEMBL8218870 | 0.89 | ALDH1A1 (0.54) | ALDH1A1CYP1A2LMNATSHRUSP2 | |
| SCHEMBL8228873 | 0.82 | ALDH1A1 (0.48) | PKMALDH1A1CYP1A2LMNATSHR | |
| SCHEMBL13596002 | 0.81 | LMNA (0.47) | ALDH1A1CYP1A2LMNAL3MBTL1GAA | |
| SCHEMBL13596003 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CYP1A2LMNATSHRUSP2 | |
| SCHEMBL13596006 | 0.77 | CACNA1H (0.50) | ALDH1A1CYP1A2LMNAL3MBTL1GAA | |
| SCHEMBL13596026 | 0.75 | LMNA (0.48) | ALDH1A1CYP1A2LMNAL3MBTL1GAA | |
| SCHEMBL8635894 | 0.72 | PROKR1 (0.53) | PKMALDH1A1CYP1A2LMNAL3MBTL1 | |
| SCHEMBL8218775 | 0.71 | PKM (0.48) | PKMALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL8202768 | 0.69 | CACNA1H (0.52) | LMNATSHRSMN1; SMN2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033456-A1 | SPIRO-CONDENSED AZETIDINE DERIVATIVES USEFUL IN TREATING PAIN, DIABETES AND DISORDERS OF LIPID METABILISM | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |