Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130789 | 0.85 | SMN1; SMN2 (0.53) | CA1CA2HDAC1HDAC3HDAC11 | |
| SCHEMBL18282719 | 0.83 | EPHX2 (0.53) | CA1CA2CA12CA7NPC1 | |
| SCHEMBL12622715 | 0.83 | VDR (0.50) | CA1CA2HDAC1HDAC3HDAC11 | |
| SCHEMBL28493929 | 0.81 | LMNA (0.55) | CA1CA2HDAC3HDAC11HDAC8 | |
| SCHEMBL28326346 | 0.81 | CA1 (0.48) | CA1CA2HDAC1HDAC3HDAC11 | |
| SCHEMBL28326344 | 0.81 | SMN1; SMN2 (0.49) | CA1CA2HDAC1HDAC3HDAC11 | |
| SCHEMBL4582345 | 0.78 | MAPT (0.54) | CA1CA2CA12CA7NPC1 | |
| SCHEMBL12378828 | 0.78 | MEN1 (0.52) | CA1CA2CA12CA7NPC1 | |
| SCHEMBL9419326 | 0.78 | MAPT (0.54) | CA1CA2HDAC1HDAC3HDAC11 | |
| SCHEMBL23310334 | 0.78 | POLB (0.62) | CA1CA2CA12CA7NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024922-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | WYETH (US) | 2008-02-28 | — | — | WO | disclosed |