SCHEMBL8227397

SCHEMBL8227397

CN(C)C(=O)C(CCN1CCC(C(O)c2nc3ccccc3n2Cc2ccc(F)cc2)CC1)(c1ccccc1)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 10/20 0.47
CYP2D6 P10635 9/20 0.47
KCNH2 Q12809 6/20 0.47
OPRM1 P35372 5/20 0.47
TACR2 P21452 1/20 0.45
TACR1 P25103 1/20 0.45
DRD2 P14416 4/20 0.44
DRD3 P35462 4/20 0.44
SSTR5 P35346 3/20 0.44
TP53 P04637 2/20 0.43
DRD4 P21917 3/20 0.42
CHRM1 P11229 3/20 0.42
NR4A2 P43354 1/20 0.42
MEN1 O00255 1/20 0.42
CES2 O00748 1/20 0.42
SLC22A1 O15245 1/20 0.42
USP2 O75604 1/20 0.42
ABCB11 O95342 1/20 0.42
LMNA P02545 1/20 0.42
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8229519 0.84 HRH1 (0.49) HRH1CYP2D6KCNH2OPRM1TACR2
SCHEMBL9695586 0.80 KCNH2 (0.51) HRH1CYP2D6KCNH2OPRM1TACR2
SCHEMBL9258632 0.80 HRH1 (0.56) HRH1CYP2D6KCNH2TP53CHRM1
SCHEMBL15569367 0.77 KCNH2 (0.51) HRH1CYP2D6KCNH2SSTR5TP53
SCHEMBL9445684 0.77 HRH1 (0.49) HRH1CYP2D6KCNH2OPRM1TACR2
SCHEMBL9696461 0.77 GAA (0.49) HRH1CYP2D6KCNH2OPRM1TACR2
SCHEMBL9445676 0.77 HRH1 (0.68) HRH1CYP2D6KCNH2OPRM1TACR2
SCHEMBL9695626 0.75 KCNH2 (0.61) HRH1CYP2D6KCNH2SSTR5TP53
SCHEMBL9697130 0.75 KCNH2 (0.48) HRH1CYP2D6KCNH2OPRM1TACR2
SCHEMBL9696448 0.74 P2RX7 (0.48) HRH1CYP2D6KCNH2OPRM1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058684-A1 GLYCINE TRANSPORT INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2000-12-13 EP disclosed
WO-1999045011-A1 GLYCINE TRANSPORT INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 1999-09-10 WO disclosed