Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258632 | 0.85 | HRH1 (0.56) | KCNH2TP53CYP2D6HRH1RAB9A | |
| SCHEMBL9695626 | 0.82 | KCNH2 (0.61) | KCNH2TP53CYP2D6HRH1RAB9A | |
| SCHEMBL9695586 | 0.82 | KCNH2 (0.51) | KCNH2HRH3TP53CYP2D6HRH1 | |
| SCHEMBL15568226 | 0.82 | HRH1 (0.63) | KCNH2HRH3HRH1 | |
| SCHEMBL9696461 | 0.78 | GAA (0.49) | KCNH2HRH3TP53CYP2D6HRH1 | |
| SCHEMBL8227397 | 0.77 | HRH1 (0.47) | KCNH2TP53CYP2D6HRH1MEN1 | |
| SCHEMBL9445676 | 0.77 | HRH1 (0.68) | KCNH2HRH3TP53CYP2D6HRH1 | |
| SCHEMBL9697130 | 0.77 | KCNH2 (0.48) | KCNH2HRH3TP53CYP2D6HRH1 | |
| SCHEMBL9696448 | 0.76 | P2RX7 (0.48) | KCNH2HRH3TP53CYP2D6HRH1 | |
| SCHEMBL13108349 | 0.75 | HSD11B1 (0.61) | CYP2D6NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | claimed |
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |