Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.79 |
| ▸ | MMP9 | P14780 | 17/20 | 0.79 |
| ▸ | MMP1 | P03956 | 17/20 | 0.79 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.61 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928954 | 0.89 | MMP13 (1.00) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL8223970 | 0.88 | MMP13 (0.62) | MMP13MMP9MMP1ADAM17MMP2 | |
| Hydroxyamine SCHEMBL8229937 | 0.86 | MMP13 (0.60) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL8229938 | 0.85 | MMP1 (0.58) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL8229989 | 0.85 | MMP13 (0.58) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL6932155 | 0.81 | MMP13 (1.00) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL6930481 | 0.77 | MMP13 (0.74) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL6928741 | 0.77 | MMP13 (0.66) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL6930507 | 0.76 | MMP9 (1.00) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL6930613 | 0.76 | MMP13 (1.00) | MMP13MMP9MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973512-A1 | N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998037877-A1 | N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-09-03 | — | — | WO | disclosed |