Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228577 | 0.95 | THRB (0.65) | THRBHTR1ADRD2HTR2AHDAC1 | |
| SCHEMBL8227623 | 0.94 | THRB (0.68) | THRB | |
| SCHEMBL8225456 | 0.89 | THRB (0.70) | THRB | |
| SCHEMBL8229336 | 0.85 | THRB (0.55) | THRBHDAC1NPC1 | |
| SCHEMBL8228205 | 0.84 | THRB (0.65) | THRBHDAC1 | |
| SCHEMBL8228552 | 0.84 | THRB (0.55) | THRBHTR1ADRD2HTR2AHDAC1 | |
| SCHEMBL8229487 | 0.83 | THRB (0.68) | THRBHDAC1NPC1 | |
| SCHEMBL8228641 | 0.83 | THRB (0.54) | THRBHTR1ADRD2HTR2AHDAC1 | |
| SCHEMBL8228140 | 0.82 | THRB (0.71) | THRBHDAC1 | |
| SCHEMBL8219764 | 0.82 | THRB (0.75) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007140982-A1 | SUBSTITUTED BENZOXAZOLES | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | WO | disclosed |