SCHEMBL8229336 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	THRB	P10828	11/20	0.55

▸	MC4R	P32245	1/20	0.46

▸	HDAC6	Q9UBN7	1/20	0.42

▸	F2R	P25116	1/20	0.42

▸	HDAC1	Q13547	1/20	0.42

▸	CASR	P41180	1/20	0.42

▸	NAMPT	P43490	1/20	0.41

▸	POLB	P06746	1/20	0.40

▸	TSHR	P16473	1/20	0.40

▸	NPC1	O15118	2/20	0.40

▸	RAB9A	P51151	1/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8228577	0.91	THRB (0.65)	THRBMC4RHDAC1
SCHEMBL8226029	0.88	THRB (0.53)	THRBHDAC6HDAC1NPC1
SCHEMBL8228641	0.87	THRB (0.54)	THRBMC4RHDAC1
SCHEMBL8228552	0.86	THRB (0.55)	THRBMC4RHDAC1
SCHEMBL8229319	0.86	THRB (0.55)	THRBHDAC6HDAC1NPC1
SCHEMBL8225252	0.86	THRB (0.55)	THRBHDAC1
SCHEMBL8228692	0.85	THRB (0.66)	THRBHDAC1NPC1
SCHEMBL8229321	0.85	THRB (0.54)	THRBHDAC6HDAC1CASRPOLB
SCHEMBL8225217	0.85	THRB (0.52)	THRBHDAC6HDAC1NAMPTNPC1
SCHEMBL8227623	0.84	THRB (0.68)	THRBCASRPOLBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2007140982-A1	SUBSTITUTED BENZOXAZOLES	BAYER HEALTHCARE AG (DE)	2007-12-13	—	—	WO	disclosed