SCHEMBL822925

SCHEMBL822925

COCCOc1nc(N)c2nc(Br)n(Cc3ccc(C#N)cc3)c2n1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 18/20 0.60
NUDT1 P36639 1/20 0.47
ADORA2A P29274 1/20 0.42
ADORA1 P30542 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12175835 0.89 TLR7 (0.64) TLR7NUDT1
SCHEMBL2058803 0.88 TLR7 (0.56) TLR7NUDT1
SCHEMBL21449006 0.88 TLR7 (0.54) TLR7
SCHEMBL2058924 0.88 TLR7 (0.60) TLR7NUDT1
SCHEMBL43087 0.88 TLR7 (0.60) TLR7NUDT1
SCHEMBL16481784 0.87 TLR7 (0.61) TLR7NUDT1ADORA2AADORA1
SCHEMBL17154083 0.87 TLR7 (0.61) TLR7NUDT1
SCHEMBL12305225 0.87 TLR7 (0.53) TLR7NUDT1
SCHEMBL7205658 0.86 TLR7 (0.60) TLR7NUDT1
SCHEMBL509587 0.86 TLR7 (0.74) TLR7NUDT1ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083853-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME GENMAB AS (DK) 2026-03-26 US disclosed
EP-4608451-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME Genmab A/S (DK) 2025-09-03 EP disclosed
US-20240261427-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-08-08 US disclosed
US-20240245796-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-07-25 US disclosed
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-06-27 US disclosed
US-20240207418-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-06-27 US disclosed
WO-2024092067-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME PROFOUNDBIO US CO. (US) 2024-05-02 WO disclosed
US-20210213010-A1 TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS DANMARKS TEKNISKE UNIVERSITET (DK) 2021-07-15 US disclosed
EP-2903987-B1 PHOSPHOLIPID DRUG ANALOGS UROGEN PHARMA LTD (IL) 2017-09-20 EP disclosed
US-9540407-B2 Phospholipid drug analogs UROGEN PHARMA LTD (IL) 2017-01-10 US disclosed
WO-2011134669-A1 METHODS FOR INDUCING AN IMMUNE RESPONSE TELORMEDIX SA (CH) 2011-11-03 WO disclosed
CN-101790380-A The conjugate and the application thereof of synthetic TLR agonist UNIV CALIFORNIA 2010-07-28 CN disclosed
US-20090324551-A1 TLR AGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) 2009-12-31 US disclosed
US-20090324551-A1 TLR AGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) 2009-12-31 US disclosed
US-20090324551-A1 TLR AGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) 2009-12-31 US disclosed
EP-2125007-A2 CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR Regents of the University of California (US) 2009-12-02 EP disclosed
WO-2008115319-A2 CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-25 WO disclosed
WO-2008115319-A2 CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-25 WO disclosed
EP-1931352-A2 TLR AGONISTS The Regents of the University of California Office of Technology Transfer (US) 2008-06-18 EP disclosed
WO-2007024707-A2 TLR AGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260083853-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME CD74, HACD3, FCGR2A TLR7 3594/4885NUDT1 4667/4885ADORA2A 4596/4885
US-20090324551-A1 TLR AGONISTS TLR3, TLR1, TLR5 TLR7 6/4885NUDT1 2186/4885ADORA2A 257/4885
US-20240207418-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 TLR7 3234/4885NUDT1 2487/4885ADORA2A 4001/4885
US-20210213010-A1 TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS TLR7, TLR9, TLR8 TLR7 1/4885NUDT1 628/4885ADORA2A 415/4885
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 TLR7 3234/4885NUDT1 2487/4885ADORA2A 4001/4885
US-20240261427-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 TLR7 3234/4885NUDT1 2487/4885ADORA2A 4001/4885
US-20240245796-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 TLR7 3234/4885NUDT1 2487/4885ADORA2A 4001/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.