Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | MMP2 | P08253 | 3/20 | 0.62 |
| ▸ | MMP9 | P14780 | 3/20 | 0.62 |
| ▸ | MMP12 | P39900 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765157 | 0.88 | HPGD (0.78) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL6933325 | 0.85 | CYP2C9 (0.74) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL8228112 | 0.85 | MMP2 (0.76) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL11006463 | 0.84 | CYP2C9 (0.60) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL3640100 | 0.84 | CYP2C9 (0.72) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL10049356 | 0.84 | CYP2C9 (0.72) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL27971821 | 0.84 | CYP2C9 (0.72) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL4734978 | 0.84 | CYP2C9 (0.72) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL2562284 | 0.83 | CYP2C9 (0.54) | CYP2C9CYP2C19HPGDMMP2MMP9 | |
| SCHEMBL4438683 | 0.82 | CYP2C9 (0.69) | CYP2C9CYP2C19HPGDMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | SERPINB1, ZFX, MMP2 | CYP2C9 472/4885CYP2C19 353/4885HPGD 643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.