Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2839974 | 0.85 | P2RX7 (0.35) | P2RX7OPRM1SIGMAR1LMNA | |
| SCHEMBL12335924 | 0.77 | RIPK1 (0.39) | P2RX7 | |
| SCHEMBL7591113 | 0.76 | EPHX1 (0.43) | P2RX7 | |
| SCHEMBL12070763 | 0.75 | TSHR (0.40) | P2RX7OPRM1LMNA | |
| SCHEMBL4529410 | 0.75 | P2RX7 (0.40) | P2RX7LMNA | |
| SCHEMBL15285632 | 0.74 | HCRTR2 (0.42) | P2RX7 | |
| SCHEMBL12308394 | 0.73 | MMP8 (0.30) | — | |
| SCHEMBL12335923 | 0.73 | RIPK1 (0.41) | LMNA | |
| SCHEMBL16057260 | 0.72 | P2RX7 (0.38) | P2RX7LMNA | |
| SCHEMBL29713169 | 0.70 | HCRTR2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007789-B1 | Spirocyclic HCV/HIV inhibitors and their uses | NOVARTIS AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2007133865-A2 | HCV/HIV INHIBITORS AN THEIR USES | NOVARTIS AG (CH) | 2007-11-22 | — | — | WO | disclosed |