Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 3/20 | 0.59 |
| ▸ | CASP6 | P55212 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 11/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230222 | 0.85 | MAPT (0.67) | GFERCASP6MAPTGAAKDM4E | |
| SCHEMBL4994240 | 0.85 | GFER (0.61) | GFERCASP6MAPTGAANPC1 | |
| SCHEMBL28705770 | 0.83 | ALDH1A1 (0.51) | GFERMAPTGAANPC1KDM4E | |
| SCHEMBL23911877 | 0.82 | GLA (0.56) | GFERCASP6MAPTGAANPC1 | |
| SCHEMBL26297059 | 0.82 | HRH3 (0.54) | MAPTGAANPC1KDM4ELMNA | |
| SCHEMBL21471586 | 0.81 | MAPT (0.56) | GFERCASP6MAPTGAANPC1 | |
| SCHEMBL30230328 | 0.81 | MAPT (0.49) | GFERMAPTGAANPC1KDM4E | |
| SCHEMBL1813106 | 0.80 | GFER (0.68) | GFERCASP6MAPTGAAKDM4E | |
| SCHEMBL23751019 | 0.80 | ADAMTS5 (0.44) | MAPTGAANPC1KDM4EL3MBTL1 | |
| SCHEMBL6508169 | 0.80 | GFER (0.59) | GFERCASP6MAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |