Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.39 |
| ▸ | MEN1 | O00255 | 8/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233896 | 0.98 | MAPT (0.45) | MAPTL3MBTL1MAPK1ALDH1A1EGFR | |
| SCHEMBL8233894 | 0.87 | KMT2A (0.50) | MAPTMAPK1ALDH1A1EGFRNSD2 | |
| SCHEMBL8232554 | 0.87 | L3MBTL1 (0.50) | MAPTL3MBTL1ALDH1A1NSD2KMT2A | |
| SCHEMBL8231190 | 0.81 | POLB (0.47) | MAPTL3MBTL1MAPK1ALDH1A1EGFR | |
| SCHEMBL14363928 | 0.78 | MAPT (0.43) | MAPTL3MBTL1MAPK1ALDH1A1EGFR | |
| SCHEMBL14363927 | 0.77 | MAPT (0.42) | MAPTL3MBTL1MAPK1ALDH1A1EGFR | |
| SCHEMBL29698264 | 0.72 | PARP1 (0.55) | MAPTL3MBTL1MAPK1ALDH1A1EGFR | |
| SCHEMBL8231662 | 0.71 | LMNA (0.52) | MAPTMAPK1ALDH1A1EGFRKMT2A | |
| SCHEMBL20887136 | 0.69 | ALDH1A1 (0.46) | MAPTL3MBTL1MAPK1ALDH1A1EGFR | |
| SCHEMBL25027414 | 0.67 | KMT2A (0.48) | MAPTL3MBTL1ALDH1A1KMT2ATLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098169-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | disclosed |