Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 5/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592801 | 0.90 | AKT1 (0.33) | CYP2C19AKT1HTR6PIK3C3 | |
| SCHEMBL8242555 | 0.81 | CCR5 (0.31) | — | |
| SCHEMBL12346679 | 0.77 | L3MBTL1 (0.40) | CYP2C19HTR6PIK3C3PTGDR2PKM | |
| SCHEMBL4633196 | 0.75 | CYP2C19 (0.46) | CYP2C19METENPP3ENPP1HTR6 | |
| SCHEMBL4584318 | 0.75 | PIK3C3 (0.31) | CYP2C19PIK3C3 | |
| SCHEMBL4592495 | 0.72 | AKT1 (0.46) | CYP2C19AKT1ENPP3ENPP1HTR6 | |
| SCHEMBL8243099 | 0.71 | AKT1 (0.47) | AKT1L3MBTL1 | |
| SCHEMBL4583522 | 0.70 | AKT1 (0.41) | CYP2C19AKT1ENPP3ENPP1PIK3C3 | |
| SCHEMBL4592678 | 0.69 | AKT1 (0.46) | CYP2C19AKT1PIK3C3KLKB1 | |
| SCHEMBL8233302 | 0.69 | AKT1 (0.63) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |