Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12942240 | 0.90 | MDM2 (0.43) | RORBKMT2AMAPK14KMOTRPM8 | |
| SCHEMBL12942053 | 0.90 | MDM2 (0.43) | RORBKMT2AMAPK14KMOTRPM8 | |
| SCHEMBL8236048 | 0.89 | XDH (0.44) | RORBMAPK14PIN1PDE4APDE4C | |
| SCHEMBL8236352 | 0.89 | XDH (0.44) | RORBMAPK14PIN1PDE4APDE4C | |
| SCHEMBL8238500 | 0.89 | ALDH1A1 (0.50) | RORBKMT2AMAPK14KMOPIN1 | |
| SCHEMBL12942047 | 0.88 | RORB (0.41) | RORBKMT2AMAPK14KMOTRPM8 | |
| SCHEMBL8294962 | 0.85 | PTGDR2 (0.43) | RORBKMT2AMAPK14PDE4APDE4C | |
| SCHEMBL8285414 | 0.85 | PTGDR2 (0.43) | RORBKMT2AMAPK14PDE4APDE4C | |
| SCHEMBL12942142 | 0.84 | NPC1 (0.45) | RORBKMT2AKMOTRPM8PIN1 | |
| SCHEMBL8304828 | 0.82 | PTGDR2 (0.40) | RORBKMT2AMAPK14ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467381-B1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND THIER USE FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO KG (DE) | 2014-04-30 | — | — | EP | disclosed |
| EP-2467381-B1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND THIER USE FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO KG (DE) | 2014-04-30 | — | — | EP | disclosed |
| US-8575357-B2 | Substituted (thiazolyl-carbonyl)imidazolidinones and use thereof | AICURIS GMBH & CO. KG (DE) | 2013-11-05 | — | — | US | disclosed |
| US-8575357-B2 | Substituted (thiazolyl-carbonyl)imidazolidinones and use thereof | AICURIS GMBH & CO. KG (DE) | 2013-11-05 | — | — | US | disclosed |
| US-8575357-B2 | Substituted (thiazolyl-carbonyl)imidazolidinones and use thereof | AICURIS GMBH & CO. KG (DE) | 2013-11-05 | — | — | US | disclosed |
| US-20130045999-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2013-02-21 | — | — | US | disclosed |
| US-20130045999-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2013-02-21 | — | — | US | disclosed |
| US-20130045999-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2013-02-21 | — | — | US | disclosed |
| EP-2467381-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011020822-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2011-02-24 | — | — | WO | disclosed |
| WO-2011020822-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2011-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130045999-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF | TPMT, AADAC, PAICS | RORB 370/4885KMT2A 1460/4885MAPK14 2030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.