SCHEMBL823591

SCHEMBL823591

O=C(CCCCCNC(=O)c1ccccc1S)Nc1cccnc1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 12/20 0.61
HDAC1 Q13547 12/20 0.61
HDAC4 P56524 10/20 0.61
HDAC7 Q8WUI4 10/20 0.61
HDAC2 Q92769 10/20 0.61
HDAC10 Q969S8 10/20 0.61
HDAC11 Q96DB2 10/20 0.61
HDAC8 Q9BY41 10/20 0.61
HDAC6 Q9UBN7 10/20 0.61
HDAC9 Q9UKV0 10/20 0.61
HDAC5 Q9UQL6 10/20 0.61
LMNA P02545 1/20 0.58
POLB P06746 1/20 0.58
CDK2 P24941 1/20 0.55
FLT4 P35916 1/20 0.55
EPHX2 P34913 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL823656 0.87 HDAC4 (0.65) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL823555 0.87 HDAC4 (0.65) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL823655 0.87 HDAC4 (0.65) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL823563 0.87 HDAC4 (0.65) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL823592 0.86 HDAC3 (0.56) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL13816931 0.86 HDAC1 (0.67) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL823572 0.86 HDAC3 (0.58) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL3626901 0.84 HDAC3 (0.64) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL14987895 0.82 HDAC3 (0.64) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL5239381 0.81 HDAC1 (0.74) HDAC3HDAC1HDAC4HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-08-05 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed
EP-2714924-B1 HDAC Inhibitors for use in the treatment of Gaucher's disease, von Hippel-Lindau disease, phaeochromocytoma and paragangliomas. LIXTE BIOTECHNOLOGY INC (US) 2018-03-21 EP disclosed
EP-2318005-B1 NEUROPROTECTIVE AGENTS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES LIXTE BIOTECHNOLOGY INC (US) 2017-11-01 EP disclosed
EP-2200439-B1 HDAC INHIBITORS LIXTE BIOTECHNOLOGY INC (US) 2017-03-22 EP disclosed
WO-2010014220-A1 NEUROPROTECTIVE AGENTS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES LIXTE BIOTECHNOLOGY, INC. (US) 2010-02-04 WO disclosed
US-20100029640-A1 Neuroprotective agents for the prevention and treatment of neurodegenerative diseases LIXTE BIOTECHNOLOGY, INC. 2010-02-04 US disclosed
US-20100029640-A1 Neuroprotective agents for the prevention and treatment of neurodegenerative diseases LIXTE BIOTECHNOLOGY, INC. 2010-02-04 US disclosed
US-20090143445-A1 HDAC Inhibitors JOHN P. WHITE, ESQ 2009-06-04 US disclosed
US-20090143445-A1 HDAC Inhibitors JOHN P. WHITE, ESQ 2009-06-04 US disclosed
WO-2009045440-A1 HDAC INHIBITORS LIXTE BIOTECHNOLOGY HOLDINGS, INC. (US) 2009-04-09 WO disclosed
WO-2009045440-A1 HDAC INHIBITORS LIXTE BIOTECHNOLOGY HOLDINGS, INC. (US) 2009-04-09 WO disclosed
WO-2009020565-A1 USE OF PHOSPHATES TO TREAT NEUROBLASTOMAS AND MEDULLOGASTOMAS LIXTE BIOTECHNOLOGY, INC. (US) 2009-02-12 WO disclosed
US-20090035292-A1 Use of phosphatases to treat neuroblastomas and medulloblastomas LIXTE BIOTECHNOLOGY, INC. 2009-02-05 US disclosed
US-20090035292-A1 Use of phosphatases to treat neuroblastomas and medulloblastomas LIXTE BIOTECHNOLOGY, INC. 2009-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029640-A1 Neuroprotective agents for the prevention and treatment of neurodegenerative diseases SNCA, NLN, HTT HDAC3 429/4885HDAC1 417/4885HDAC4 191/4885
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ATXN2L, ATXN2, ATXN10 HDAC3 1962/4885HDAC1 1805/4885HDAC4 2320/4885
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 HDAC3 3028/4885HDAC1 1578/4885HDAC4 2054/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 HDAC3 3028/4885HDAC1 1578/4885HDAC4 2054/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 HDAC3 2178/4885HDAC1 2341/4885HDAC4 2401/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN HDAC3 1324/4885HDAC1 927/4885HDAC4 785/4885
US-20090143445-A1 HDAC Inhibitors HDAC3, HDAC7, HDAC4 HDAC3 1/4885HDAC1 6/4885HDAC4 3/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF HDAC3 1673/4885HDAC1 650/4885HDAC4 1375/4885
US-20090035292-A1 Use of phosphatases to treat neuroblastomas and medulloblastomas PPME1, PNKP, PPP6C HDAC3 120/4885HDAC1 18/4885HDAC4 101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.