SCHEMBL8236186

SCHEMBL8236186

CC(c1ccccc1)N1CCC(Oc2cc(F)nc3c(CF)cccc23)CC1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN8A Q9UQD0 20/20 0.46
SCN1A P35498 12/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8236177 0.90 SCN8A (0.38) SCN8ASCN1A
SCHEMBL8238217 0.89 HRH3 (0.38)
SCHEMBL5526609 0.87 SCN8A (0.49) SCN8ASCN1A
SCHEMBL8235974 0.87 MCHR1 (0.35) SCN8ASCN1A
SCHEMBL5523125 0.85 SCN8A (0.46) SCN8ASCN1A
SCHEMBL8230091 0.84 SCN8A (0.43) SCN8ASCN1A
SCHEMBL8236222 0.83 HRH3 (0.39) SCN8ASCN1A
SCHEMBL8231334 0.81 MAPK14 (0.35) SCN8ASCN1A
SCHEMBL8238215 0.81 HRH3 (0.39)
SCHEMBL8236599 0.79 POLB (0.38) SCN8ASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007071055-A1 COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS PAINCEPTOR PHARMA CORPORATION (CA) 2007-06-28 WO disclosed