Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494924 | 0.87 | KMT2A (0.45) | PDE4BPDE4DPDE7APDE3APDE7B | |
| SCHEMBL4985664 | 0.81 | PDE4B (0.43) | PDE4BPDE4DPDE7APDE3APDE7B | |
| SCHEMBL3493425 | 0.72 | MAPT (0.53) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL8235805 | 0.71 | ALDH1A1 (0.50) | KMT2AMEN1POLBLMNAKDM4E | |
| SCHEMBL3492624 | 0.70 | MAPT (0.41) | KMT2AMEN1POLBLMNAKDM4E | |
| SCHEMBL3495080 | 0.68 | NOTUM (0.45) | KDM4EALDH1A1HPGD | |
| SCHEMBL3494813 | 0.68 | NOTUM (0.48) | KMT2AMEN1LMNAALDH1A1HPGD | |
| SCHEMBL3493942 | 0.68 | TSHR (0.47) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL3494927 | 0.67 | KMT2A (0.43) | KMT2AALOX5MEN1ALDH1A1ATM | |
| SCHEMBL4984950 | 0.67 | CA1 (0.41) | KMT2AMEN1POLBCA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |