Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.41 |
| ▸ | TUBB | P07437 | 8/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985664 | 0.87 | PDE4B (0.43) | ALDH1A1HPGDMAPK1L3MBTL1KDM4E | |
| SCHEMBL3494052 | 0.83 | NOTUM (0.55) | NOTUMTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28745134 | 0.78 | ALDH1A1 (0.55) | NOTUMALDH1A1HPGDMYCTDP1 | |
| SCHEMBL3494831 | 0.77 | KMT2A (0.48) | NOTUMALDH1A1TDP1 | |
| SCHEMBL3495038 | 0.77 | PLA2G2A (0.39) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3494283 | 0.76 | MAPT (0.54) | NOTUMALDH1A1HPGDMAPK1MYC | |
| SCHEMBL3493425 | 0.74 | MAPT (0.53) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL3491793 | 0.73 | NOTUM (0.68) | NOTUMALDH1A1HPGDMYC | |
| SCHEMBL3494596 | 0.72 | NOTUM (0.71) | NOTUMALDH1A1HPGDTHRBKDM4E | |
| Methyl Syringate SCHEMBL5152857 | 0.71 | KDM4E (0.51) | ALDH1A1HPGDMAPK1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140178503-A1 | CYCLOHEXYL UREA MODULATORS OF D2 RECEPTORS AND/OR D3 RECEPTORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-13 | — | — | US | disclosed |
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-13 | — | — | US | disclosed |
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-13 | — | — | US | disclosed |
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | REN, AGTR1, AGTR2 | NOTUM 1289/4885TUBB4A 4695/4885TUBB 4606/4885 |
| US-20140178503-A1 | CYCLOHEXYL UREA MODULATORS OF D2 RECEPTORS AND/OR D3 RECEPTORS | UTS2R, VDR, PTGDR | NOTUM 4180/4885TUBB4A 3467/4885TUBB 3367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.