Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PCNA | P12004 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494085 | 0.82 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10CASP1 | |
| SCHEMBL3494924 | 0.73 | KMT2A (0.45) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| SCHEMBL8236282 | 0.71 | PDE4B (0.40) | ALDH1A1KDM4EHPGDKMT2AMEN1 | |
| SCHEMBL3496056 | 0.70 | CA1 (0.40) | KMT2AMEN1POLBLMNA | |
| SCHEMBL4984950 | 0.69 | CA1 (0.41) | KMT2AMEN1POLBLMNA | |
| SCHEMBL3495080 | 0.67 | NOTUM (0.45) | ALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL3494052 | 0.67 | NOTUM (0.55) | ALDH1A1HPGDKMT2AMEN1MAPT | |
| SCHEMBL8327592 | 0.66 | FKBP1A (1.00) | ALDH1A1HPGDKMT2AMEN1FKBP1A | |
| SCHEMBL8328048 | 0.66 | KMT2A (0.68) | KDM4EHPGDKMT2AMEN1FKBP1A | |
| SCHEMBL2948248 | 0.65 | FKBP1A (0.57) | ALDH1A1KDM4EHPGDHSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |