Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | PSMC4 | P43686 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347614 | 0.84 | LMNA (0.42) | ADORA3SRCABL1VCPLRRK2 | |
| SCHEMBL5063566 | 0.83 | VCP (0.58) | HIF1ASRCABL1VCPPSMC4 | |
| SCHEMBL7003043 | 0.83 | SRC (0.40) | UTS2RHIF1AADORA3SRCABL1 | |
| SCHEMBL8369837 | 0.81 | LRRK2 (0.41) | UTS2RADORA3SRCABL1VCP | |
| SCHEMBL7000781 | 0.74 | SRC (0.41) | UTS2RADORA3SRCABL1PDE4A | |
| SCHEMBL7000322 | 0.67 | SRC (0.44) | ADORA3SRCABL1VCPPSMC4 | |
| SCHEMBL6997527 | 0.66 | SRC (0.46) | SRCABL1VCPPSMC4PDE4A | |
| SCHEMBL7003040 | 0.66 | SRC (0.41) | SRCABL1VCPPSMC4PDE4A | |
| SCHEMBL8347612 | 0.66 | SRC (0.58) | ADORA3SRCABL1VCPPSMC4 | |
| SCHEMBL7835545 | 0.66 | ALDH1A1 (0.47) | ADORA3VCPPSMC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017823-A2 | ENGINEERED PROTEIN KINASES WHICH CAN UTILIZE MODIFIED NUCLEOTIDE TRIPHOSPHATE SUBSTRATES | PRINCETON UNIVERSITY (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-1998035048-A2 | ENGINEERED PROTEIN KINASES WHICH CAN UTILIZE MODIFIED NUCLEOTIDE TRIPHOSPHATE SUBSTRATES | PRINCETON UNIVERSITY (US) | 1998-08-13 | — | — | WO | disclosed |