Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 5/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30417045 | 1.00 | MGAM (0.61) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL28665600 | 0.86 | MGAM (0.58) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL8906407 | 0.85 | ALDH1A1 (0.55) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL29456863 | 0.83 | MAPT (0.66) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL27668767 | 0.83 | MAPT (0.66) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL9664008 | 0.82 | ALDH1A1 (0.60) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL14392711 | 0.81 | MGAM (0.61) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL17035499 | 0.81 | MAPT (0.64) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL2400093 | 0.81 | MGAM (0.61) | MGAMALDH1A1MAPTGAACNR2 | |
| SCHEMBL1459295 | 0.81 | MGAM (0.61) | MGAMALDH1A1MAPTGAACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059799-B2 | Process for preparation of eribulin and intermediates thereof | DR. REDDY'S LABORATORIES LIMITED. (IN) | 2021-07-13 | — | — | US | disclosed |
| CN-105884743-B | Metal enzyme inhibitor compound | 威尔金制药(NC)有限公司 | 2019-08-06 | — | — | CN | disclosed |
| CN-109400594-A | Metal enzyme inhibitor compound | 威尔金制药(NC)有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-103781775-B | Metal enzyme inhibitor compound | 威尔金制药有限公司 | 2016-11-16 | — | — | CN | disclosed |
| WO-2016172631-A2 | SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-10-27 | — | — | WO | disclosed |
| CN-105884743-A | Metalloenzyme inhibitor compounds | 威尔金制药有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-103957908-A | Substituted aminothiazoles as inhibitors of cancer including hepatocellular carcinoma and as inhibitors of hepatitis virus replication | INST HEPATITIS & VIRUS RES | 2014-07-30 | — | — | CN | disclosed |
| US-20120225903-A1 | Novel 2-Substituted Quinoline Derivatives, And Method For Preparing Same | ALPHA CHIMICA (FR) | 2012-09-06 | — | — | US | disclosed |
| US-20120225903-A1 | Novel 2-Substituted Quinoline Derivatives, And Method For Preparing Same | ALPHA CHIMICA (FR) | 2012-09-06 | — | — | US | disclosed |
| US-20110046157-A1 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| WO-2009150318-A1 | NOVEL 2-SUBSTITUTED QUINOLINE DERIVATIVES, AND METHOD FOR PREPARING SAME | INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (FR) | 2009-12-17 | — | — | WO | disclosed |
| US-20090192138-A1 | COMPOUNDS | BAESCHLIN DANIEL KASPAR | 2009-07-30 | — | — | US | disclosed |
| WO-2007071738-A1 | CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS | NOVARTIS AG (CH) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059799-B2 | Process for preparation of eribulin and intermediates thereof | ERLIN1, ERLIN2, MAN1B1 | MGAM 3733/4885ALDH1A1 1325/4885MAPT 3504/4885 |
| US-20120225903-A1 | Novel 2-Substituted Quinoline Derivatives, And Method For Preparing Same | THPO, QARS1, QTRT2 | MGAM 2793/4885ALDH1A1 3343/4885MAPT 3157/4885 |
| US-20090192138-A1 | COMPOUNDS | DPP4, DPP3, DPP8 | MGAM 288/4885ALDH1A1 363/4885MAPT 2735/4885 |
| US-20110046157-A1 | Substituted hydroxamic acids and uses thereof | HDAC6, HDAC5, HDAC1 | MGAM 3939/4885ALDH1A1 1220/4885MAPT 2380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.