Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30417045 | 0.85 | MGAM (0.61) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL8237398 | 0.85 | MGAM (0.61) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL8906409 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL9664008 | 0.82 | ALDH1A1 (0.60) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL5158859 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL5158144 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL5160087 | 0.79 | ALDH1A1 (0.58) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL5160847 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL1460111 | 0.79 | KMT2A (0.57) | ALDH1A1MAPTGAAMGAMHDAC8 | |
| SCHEMBL28665600 | 0.79 | MGAM (0.58) | ALDH1A1MAPTGAAMGAMHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |