Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275673 | 0.87 | TACR2 (0.46) | SIGMAR1KDM4EALDH1A1POLBTACR2 | |
| SCHEMBL4271169 | 0.74 | TACR2 (0.43) | ALDH1A1TACR2CACNA1GCACNA1HPRKCB | |
| SCHEMBL4279734 | 0.73 | TACR2 (0.60) | KDM4EALDH1A1POLBTACR2SLC6A4 | |
| SCHEMBL5047955 | 0.73 | CACNA1G (0.39) | SIGMAR1KDM4EALDH1A1POLBTACR2 | |
| SCHEMBL4272230 | 0.72 | TACR2 (0.42) | TACR2SLC6A3CACNA1GCACNA1HCYP3A4 | |
| SCHEMBL5048006 | 0.66 | CACNA1G (0.38) | TACR2CACNA1GCACNA1HPRKCBCYP3A4 | |
| SCHEMBL2794338 | 0.66 | CACNA2D1 (0.50) | ALDH1A1TACR2SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL5051949 | 0.65 | TACR2 (0.37) | TACR2CACNA1GCACNA1HPRKCBCYP3A4 | |
| SCHEMBL5053752 | 0.65 | GRM5 (0.38) | POLBTACR2MAPK1SLC6A3SLC6A2 | |
| SCHEMBL2794421 | 0.62 | CACNA2D1 (0.66) | ALDH1A1POLBSLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007071035-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-06-28 | — | — | WO | disclosed |