Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 5/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233787 | 0.85 | HDAC3 (0.43) | SYKCTSSCTSKCTSBMAPT | |
| SCHEMBL14114831 | 0.81 | AKT1 (0.45) | AKT1AKT2AKT3MMP12 | |
| SCHEMBL12679599 | 0.81 | AKT1 (0.45) | AKT1AKT2AKT3MMP12 | |
| SCHEMBL12838327 | 0.79 | SYK (0.41) | SYKCTSSCTSKCTSBCTSL | |
| SCHEMBL12679569 | 0.78 | MMP12 (0.38) | AKT1SYKCTSSCTSKCTSB | |
| SCHEMBL12679579 | 0.77 | AKT1 (0.38) | AKT1SYKCTSSCTSKAKT2 | |
| SCHEMBL12679604 | 0.76 | ROCK2 (0.38) | AKT1SYKCTSSCTSKAKT2 | |
| SCHEMBL6690446 | 0.76 | CTSK (0.48) | SYKCTSSCTSKCTSBMAPT | |
| SCHEMBL12679233 | 0.76 | AKT1 (0.40) | AKT1SYKCTSSCTSK | |
| SCHEMBL12679232 | 0.75 | SYK (0.38) | SYKCTSSCTSKCTSBAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |