Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908271 | 0.74 | — | — | |
| SCHEMBL8243435 | 0.73 | DDAH1 (0.34) | DDAH1ALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL12145396 | 0.68 | — | — | |
| SCHEMBL13706923 | 0.68 | TSHR (0.36) | TSHR | |
| SCHEMBL28065431 | 0.65 | KDM4E (0.44) | TSHRALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL15830518 | 0.65 | ALDH1A1 (0.50) | TSHRALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL16589858 | 0.65 | TSHR (0.69) | TSHRALDH1A1HPGDCNR1HTT | |
| SCHEMBL14209341 | 0.65 | PAOX (0.42) | TSHRDDAH1ALDH1A1LMNAMEN1 | |
| SCHEMBL14705125 | 0.65 | — | — | |
| SCHEMBL14074126 | 0.64 | TSHR (0.52) | TSHRALDH1A1HTTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076379-A2 | 4,7-DIHYDROTHIENO[2,3-B]PYRIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS | GILEAD COLORADO, INC. (US) | 2007-07-05 | — | — | WO | disclosed |