Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 0.56 |
| ▸ | MEN1 | O00255 | 13/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 2/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8239298 | 0.86 | KMT2A (0.60) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL11913677 | 0.86 | MAPT (0.65) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL8232030 | 0.85 | MAPT (0.56) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL11918184 | 0.83 | MAPT (0.65) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL12417187 | 0.83 | MAPT (0.65) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL12417208 | 0.82 | MAPT (0.59) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL12417175 | 0.80 | MAPT (0.61) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL27776235 | 0.80 | MAPT (0.63) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL6721154 | 0.79 | CTSL (0.58) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL12717686 | 0.76 | GAA (0.61) | MAPTMEN1KMT2AGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1790345-A1 | Triazin beta-secretase inhibitors | Esbatech AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2007051333-A1 | TRIAZINE BETA-SECRETASE INHIBITORS | ONCALIS AG (CH) | 2007-05-10 | — | — | WO | disclosed |