SCHEMBL8243764

SCHEMBL8243764

Nc1cc(C(F)F)c(Cl)cc1F

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.35
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30977563 0.77 ALDH1A1 (0.39) ALDH1A1
SCHEMBL1477638 0.76 GAA (0.53) GAAALDH1A1
SCHEMBL30573328 0.76 GAA (0.53) GAAALDH1A1
SCHEMBL14578394 0.76 GAA (0.53) GAAALDH1A1
SCHEMBL8961372 0.75 LMNA (0.32)
SCHEMBL10553307 0.75 GAA (0.32) GAA
SCHEMBL17785693 0.74 ALDH1A1 (0.33) ALDH1A1
SCHEMBL1397082 0.74 KDM1A (0.43) GAAALDH1A1
SCHEMBL29939627 0.74 KDM1A (0.43) GAAALDH1A1
SCHEMBL6666210 0.74 GAA (0.58) GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007036718-A2 COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE GLAXO GROUP LIMITED (GB) 2007-04-05 WO disclosed