SCHEMBL824537

SCHEMBL824537

CC(C)(c1ccccc1)c1cc2c(c(C(C)(C)c3ccccc3)c1)OC(=O)C2c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.44
CYP3A4 P08684 3/20 0.33
MAPT P10636 2/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
MAPK1 P28482 1/20 0.33
HTR2B P41595 1/20 0.33
ALDH1A1 P00352 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
NR3C2 P08235 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175414 0.88 GAA (0.36) GAA
SCHEMBL2612450 0.85 GAA (0.50) GAACYP3A4MAPTLMNATP53
SCHEMBL31247883 0.84 GAA (0.46) GAACYP3A4MAPTLMNATP53
SCHEMBL466160 0.84 GAA (0.46) GAACYP3A4MAPTLMNATP53
SCHEMBL7156859 0.83 ESR1 (0.36) CYP3A4ALDH1A1ESR1ESR2MEN1
SCHEMBL824482 0.78 GAA (0.63) GAACYP3A4MAPTALDH1A1ESR1
SCHEMBL11987177 0.78 GAA (0.59) GAAMAPTALDH1A1
SCHEMBL2612424 0.77 GAA (0.39) GAACYP3A4MAPTCYP1A2ALDH1A1
SCHEMBL25723567 0.77 GAA (0.48) GAACYP3A4TP53ALDH1A1ESR1
SCHEMBL2612468 0.77 GAA (0.65) GAACYP3A4MAPTALDH1A1ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6224791-B1 PHENYLBENZOFURAN-2-ONE WITH PHOSPHITE DOVER CHEMICAL CORPORATION 2001-05-01 US claimed
WO-1999003915-A1 LACTONE/PHOSPHITE BLENDS DOVER CHEMICAL CORPORATION (US) 1999-01-28 WO claimed
US-8142864-B2 Cellulose ester pellets, cellulose ester film, manufacturing method of cellulose ester film, polarizing plate, and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2012-03-27 US disclosed
US-8142864-B2 Cellulose ester pellets, cellulose ester film, manufacturing method of cellulose ester film, polarizing plate, and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2012-03-27 US disclosed
US-20100047480-A1 CELLULOSE ESTER PELLETS, CELLULOSE ESTER FILM, MANUFACTURING METHOD OF CELLULOSE ESTER FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY C/O KONICA MINOLTA OPTO, INC. (JP) 2010-02-25 US disclosed
US-20100047480-A1 CELLULOSE ESTER PELLETS, CELLULOSE ESTER FILM, MANUFACTURING METHOD OF CELLULOSE ESTER FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY C/O KONICA MINOLTA OPTO, INC. (JP) 2010-02-25 US disclosed
US-7470735-B2 Phenol-free phosphites DOVER CHEMICAL CORPORATION (US) 2008-12-30 US disclosed
US-7342060-B2 Process for manufacture of pentaerythritol diphosphites DOVER CHEMICAL CORPORATION (US) 2008-03-11 US disclosed
WO-2005113665-A2 PHENOL-FREE PHOSPHITES DOVER CHEMICAL CORPORATION (US) 2005-12-01 WO disclosed
US-20050131244-A1 PROCESS FOR MANUFACTURE OF PENTAERYTHRITOL DIPHOSPHITES DOVER CHEMICAL CORPORATION (US) 2005-06-16 US disclosed
US-20040180999-A1 PHENOL-FREE PHOSPHITES DOVER CHEMICAL CORPORATION (US) 2004-09-16 US disclosed
US-6770693-B2 COMPRISING BIS-(2,4-DICUMYLPHENYL) PENTAERYTHRITOL DIPHOSPHITE AND HINDERED PHENOL ANTIOXIDANTS USEFUL AS STABILIZERS AGAINST THERMOOXIDATIVE DEGRADATION OF POLYMERS DURING MELT PROCESSING DOVE CHEMICAL CORPORATION 2004-08-03 US disclosed
US-20020040081-A1 Blends of phosphites and antioxidants DOVER CHEMICAL 2002-04-04 US disclosed
US-6224791-B1 PHENYLBENZOFURAN-2-ONE WITH PHOSPHITE DOVER CHEMICAL CORPORATION 2001-05-01 US disclosed
WO-1999003915-A1 LACTONE/PHOSPHITE BLENDS DOVER CHEMICAL CORPORATION (US) 1999-01-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050131244-A1 PROCESS FOR MANUFACTURE OF PENTAERYTHRITOL DIPHOSPHITES GNPAT, DCTPP1, DERA GAA 2344/4885CYP3A4 113/4885MAPT 3929/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.