Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577956 | 0.86 | KDM4E (0.55) | ALDH1A1NPSR1HPGDLMNAMAPK1 | |
| SCHEMBL3581117 | 0.86 | HPGD (0.62) | ALDH1A1NPSR1HPGDLMNAPOLB | |
| SCHEMBL3581142 | 0.84 | MMP2 (0.47) | ALDH1A1HPGDLMNAMMP2PSMB5 | |
| SCHEMBL3578207 | 0.81 | MMP2 (0.46) | ALDH1A1HPGDLMNAMAPK1MMP2 | |
| SCHEMBL7741059 | 0.81 | MMP2 (0.54) | POLBMMP2PSMB5NFKB1NFKB2 | |
| SCHEMBL7741064 | 0.81 | MMP2 (0.54) | POLBMMP2PSMB5NFKB1NFKB2 | |
| SCHEMBL3588641 | 0.80 | RAB9A (0.48) | ALDH1A1NPSR1HPGDLMNAMAPK1 | |
| SCHEMBL2246985 | 0.78 | ADAMTS5 (0.59) | MMP2PSMB5NFKB1NFKB2RELA | |
| SCHEMBL3576509 | 0.78 | ADAMTS5 (0.62) | MAPK1MMP2MMP8 | |
| SCHEMBL3581169 | 0.78 | C3AR1 (0.57) | ALDH1A1HPGDMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |