Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 2/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27806740 | 0.79 | GRM4 (0.39) | GRM4HCAR2TDO2LMNACHRNB2 | |
| SCHEMBL21571870 | 0.77 | SLC22A12 (0.42) | GRM4HCAR2CYP2C9BRAFNPC1 | |
| SCHEMBL7958561 | 0.76 | — | — | |
| SCHEMBL8237552 | 0.75 | PIK3CA (0.35) | GRM4HCAR2LATS1LATS2ALDH1A1 | |
| SCHEMBL25124433 | 0.75 | EGFR (0.38) | GRM4HCAR2TDO2LMNACHRNB2 | |
| SCHEMBL8247975 | 0.75 | FDPS (0.47) | LMNASMN1; SMN2RAB9AMEN1ALDH1A1 | |
| SCHEMBL21571867 | 0.72 | SLC22A12 (0.46) | CYP2C9BRAFCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL14993767 | 0.71 | — | — | |
| SCHEMBL12368483 | 0.71 | IDH1 (0.39) | GRM4HCAR2TDO2LMNACHRNB2 | |
| SCHEMBL8244430 | 0.71 | SCN10A (0.37) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007045861-A1 | CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4) | GLAXO GROUP LIMITED (GB) | 2007-04-26 | — | — | WO | disclosed |