Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14007397 | 0.79 | ALDH1A1 (0.44) | SCN10ARAF1CYP11B1CYP11B2KCNH2 | |
| SCHEMBL8750751 | 0.78 | CHEK1 (0.42) | SCN10ARAF1CYP11B1CYP11B2KCNH2 | |
| SCHEMBL22205240 | 0.75 | PDK1 (0.48) | SCN10AKCNH2MALT1 | |
| SCHEMBL21605071 | 0.75 | KDM4E (0.47) | SCN10ARAF1CYP11B1CYP11B2CHRNB2 | |
| SCHEMBL8750888 | 0.74 | XDH (0.41) | SCN10ARAF1CYP11B1CYP11B2KCNH2 | |
| Hydrochloric Acid SCHEMBL21598403 | 0.73 | KDM4E (0.45) | SCN10ARAF1CYP11B1CYP11B2CHRNB2 | |
| Hydrochloric Acid SCHEMBL30147906 | 0.73 | KDM4E (0.45) | SCN10ARAF1CYP11B1CYP11B2CHRNB2 | |
| SCHEMBL8750774 | 0.73 | CHRNB2 (0.46) | RAF1CYP11B1CYP11B2CHRNB2CHRNA4 | |
| SCHEMBL21571870 | 0.72 | SLC22A12 (0.42) | SCN10A | |
| SCHEMBL936524 | 0.72 | CYP11B1 (0.47) | RAF1CYP11B1CYP11B2CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007045861-A1 | CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4) | GLAXO GROUP LIMITED (GB) | 2007-04-26 | — | — | WO | disclosed |