Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8251092 | 0.86 | TRPM8 (0.56) | SMN1; SMN2RAB9ANPC1MAPK1KMT2A | |
| SCHEMBL8251101 | 0.84 | TDP1 (0.58) | SMN1; SMN2RAB9ANPC1MAPK1MEN1 | |
| SCHEMBL8248874 | 0.80 | NOTUM (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3632818 | 0.79 | SMN1; SMN2 (0.86) | SMN1; SMN2RAB9ANPC1MAPK1MEN1 | |
| SCHEMBL8241794 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1MAPK1MEN1 | |
| SCHEMBL7748496 | 0.77 | RAB9A (0.65) | SMN1; SMN2RAB9ANPC1MAPK1PRMT5 | |
| SCHEMBL27308957 | 0.77 | ATM (0.49) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL8428018 | 0.75 | RAB9A (0.61) | SMN1; SMN2RAB9ANPC1MAPK1MEN1 | |
| SCHEMBL5696786 | 0.75 | MLYCD (0.69) | SMN1; SMN2RAB9ANPC1MAPK1MEN1 | |
| SCHEMBL4842036 | 0.75 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504431-B2 | Sulfonyl amide inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-17 | — | — | US | disclosed |
| US-7504431-B2 | Sulfonyl amide inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-17 | — | — | US | disclosed |
| US-20050245535-A1 | Sulfonyl amide inhibitors of calcium channel function | BRISTOL- MYERS SQUIBB COMPANY | 2005-11-03 | — | — | US | disclosed |
| US-20050245535-A1 | Sulfonyl amide inhibitors of calcium channel function | BRISTOL- MYERS SQUIBB COMPANY | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245535-A1 | Sulfonyl amide inhibitors of calcium channel function | CACNA1F, CACNA1A, CACNA1D | SMN1; SMN2 2190/4885RAB9A 1214/4885NPC1 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.