Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 12/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | IL6 | P05231 | 2/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8251311 | 0.90 | TLR8 (0.42) | TLR8CSF1RSOS1ALDH1A1POLB | |
| SCHEMBL8252433 | 0.89 | S1PR4 (0.36) | TLR7IL6ALDH1A1 | |
| SCHEMBL8242381 | 0.87 | TLR7 (0.35) | TLR7IL6 | |
| SCHEMBL8249741 | 0.87 | F2 (0.36) | TLR7IL6ALDH1A1 | |
| SCHEMBL8284703 | 0.86 | CSF1R (0.47) | CSF1RSOS1ALDH1A1POLBHTT | |
| SCHEMBL8242374 | 0.85 | AGTR2 (0.39) | TLR7 | |
| SCHEMBL8251906 | 0.85 | AGTR2 (0.39) | TLR7 | |
| SCHEMBL8283857 | 0.85 | CSF1R (0.57) | CSF1RALDH1A1POLBHTT | |
| SCHEMBL8248706 | 0.83 | HTT (0.46) | ALDH1A1POLBHTT | |
| SCHEMBL8284695 | 0.81 | KDM4E (0.46) | TLR8CSF1RSOS1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034835-B2 | 1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-10-11 | — | — | US | disclosed |
| US-20100183552-A1 | 1-[2-AMINO-3-(SUBSTITUTED ALKYL)-3H-BENZIMIDAZOLYLMETHYL]-3-SUBSTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AND STRUCTURAL ANALOGS | JANSSEN SCIENCES IRELAND UC (IE) | 2010-07-22 | — | — | US | disclosed |
| WO-2006136561-A1 | 1- ( 2-AMINO-3- (SUBSTITUTED ALKYL)-3H-BENZIMIDAZOIYLMETHYL) -3-SUBTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES WITH ACTIVITY ON RESPIRATORY SYNCYTIAL VIRUS | TIBOTEC PHARMACEUTICALS LTD (IE) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100183552-A1 | 1-[2-AMINO-3-(SUBSTITUTED ALKYL)-3H-BENZIMIDAZOLYLMETHYL]-3-SUBSTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AND STRUCTURAL ANALOGS | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ALK, HRH4 | TLR8 1679/4885CSF1R 4163/4885TLR7 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.