Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 12/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247680 | 0.90 | TLR8 (0.42) | TLR8CSF1RSOS1ALDH1A1POLB | |
| SCHEMBL8241914 | 0.80 | SOS1 (0.43) | TLR8CSF1RSOS1ALDH1A1POLB | |
| SCHEMBL11984813 | 0.79 | S1PR4 (0.39) | S1PR4 | |
| SCHEMBL8252433 | 0.79 | S1PR4 (0.36) | ALDH1A1S1PR4 | |
| SCHEMBL8251906 | 0.78 | AGTR2 (0.39) | S1PR4 | |
| SCHEMBL8249741 | 0.77 | F2 (0.36) | ALDH1A1S1PR4 | |
| SCHEMBL8242381 | 0.77 | TLR7 (0.35) | S1PR4 | |
| SCHEMBL8284703 | 0.76 | CSF1R (0.47) | CSF1RSOS1ALDH1A1POLBHTT | |
| SCHEMBL8242374 | 0.76 | AGTR2 (0.39) | — | |
| SCHEMBL8247681 | 0.76 | CSF1R (0.32) | TLR8CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136561-A1 | 1- ( 2-AMINO-3- (SUBSTITUTED ALKYL)-3H-BENZIMIDAZOIYLMETHYL) -3-SUBTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES WITH ACTIVITY ON RESPIRATORY SYNCYTIAL VIRUS | TIBOTEC PHARMACEUTICALS LTD (IE) | 2006-12-28 | — | — | WO | disclosed |