Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL337356 | 0.91 | OPRM1 (0.41) | OPRM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL9374437 | 0.80 | OPRM1 (0.39) | OPRM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL7811721 | 0.80 | MEN1 (0.40) | SMN1; SMN2MEN1KMT2APOLBKCNH2 | |
| SCHEMBL7815568 | 0.80 | MEN1 (0.40) | SMN1; SMN2MEN1KMT2APOLBKCNH2 | |
| SCHEMBL8764177 | 0.80 | MEN1 (0.40) | SMN1; SMN2MEN1KMT2APOLBKCNH2 | |
| SCHEMBL774037 | 0.77 | ARG1 (0.39) | ARG1ARG2 | |
| SCHEMBL7313574 | 0.76 | CYP4F2 (0.31) | ARG1ARG2 | |
| SCHEMBL10670488 | 0.75 | DDB1 (0.49) | KMT2ASLC6A2SLC6A3 | |
| SCHEMBL10957286 | 0.75 | OPRM1 (0.40) | OPRM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL28426667 | 0.75 | OPRM1 (0.40) | OPRM1SMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336136-A1 | Pyridine derivatives and their use in the treatment of psychotic disorders | GlaxoSmithKline LLC (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2007028654-A1 | PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |